The global epinephrine market size was USD 2436.69 Million in 2021 and is expected to register a revenue CAGR of 8.4% during the forecast period. Rising prevalence of anaphylaxis and increasing demand for epinephrine injections in order to treat patients with cardiac arrest, asthma, and various other diseases are some major factors driving global epinephrine market revenue growth.
Epinephrine is a hormone (also known as adrenaline) secreted by the adrenal gland present in the kidneys into the blood. This hormone is primarily used in the synthesis of glycogen. Epinephrine is also secreted at the moment of extreme emotions such as anxiety or anger, thereby resulting in elevated levels of blood pressure, along with high sugar metabolism and increased muscle strength. Under strenuous situations, electrical signals from the brain are transmitted to the kidneys, which leads to secretion of adrenalin or epinephrine. In order to maintain cardiovascular homeostasis, epinephrine has become an essential hormone, owing to its ability of supplying blood to tissues under stress. In addition, the epinephrine hormone aids in the treatment of severe allergic reactions characterized by symptoms such as skin redness, swallowing and breathing difficulties, itching, wheezing, and accelerated heart rate (tachycardia). Epinephrine is known to be highly effective against anaphylaxis. Anaphylaxis is basically a condition caused by exposure to an allergen (insects, food, stings, or medicines) that is recognized as an antigen by the human body.
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Epinephrine has effects on various parts of the human body such as liver, skin, lungs, and heart. For instance, lungs epinephrine causes the relaxation of lungs’ smooth muscles for easing the breathing process during asthma. Growing incidence of anaphylaxis is resulting in the contraction of lung muscles, which subsequently results in coughing, wheezing, shortness of breath. Inhalation of epinephrine in small doses can cause the widening of the bronchial tubes, thereby allowing air to pass through, providing short term relief. This advantage of epinephrine is increasing its demand significantly in the pharmaceutical industry, which in turn is contributing to the steady revenue growth of the global epinephrine market.
Prevalence of anaphylaxis is increasing globally, and according to the NICE (National Institute for Health and Clinical Excellence), the UK registered an estimated death count of 20, resulting from anaphylaxis. This condition is known to be an acute and potentially lethal multi-system allergic reaction. However, most consensus guidelines for the past 30 years have indicated that epinephrine is the drug of choice and the first drug that should be administered in acute anaphylaxis. It prevents or reduces upper airway mucosal edema that is laryngeal edema, hypotension, and shock through vasoconstrictor effects. A large ratio of the population suffering from various types of allergies worldwide is one of the major factors driving demand for epinephrine, which is further expected to continue to support overall market growth.
Epinephrine plays a crucial role in fight-or-flight response by elevating blood flow to muscles. Manufacturers in the market are focusing on epinephrine administration, which can be delivered intravenously through injection into the muscles. Also, manufacturers are launching drugs for different administration routes of epinephrine such as inhalation or by injecting just under the skin to increase the effectiveness of this hormone. Epinephrine auto-injector is a medical device used by patients to treat anaphylaxis by administration of doses of adrenalin or epinephrine. These portable devices contain a needle, which delivers a fixed dose of epinephrine. Rising demand for epinephrine auto-injectors for quick emergency response is expected to drive the overall revenue growth of the epinephrine market. Furthermore, increasing new product approvals and product launches by major players in the market is expected to revenue growth to a significant extent going ahead.
Doctors recommend other alternative pharmacotherapy or immunotherapy against severe allergic reactions due to adverse or side effects associated with epinephrine such as high blood pressure, abnormal heart rhythm, headache and anxiety in some cases. These are some key factors expected to hamper revenue growth of the market to some extent. Additionally, limited R&D expenditure for growing pipeline of epinephrine is another factor restricting market growth.
Product Type Outlook:
On the basis of product type, the epinephrine market is segmented into auto-injector, prefilled syringes, and ampoules and vials. The auto-injector segment accounted for largest revenue share in the global market in 2020, which can be attributed to increasing demand for prefilled auto-injectors due to quick response to this type of delivery route. Also, rapid launch of more affordable generic epinephrine products and innovations in auto-injectors are some other factors supporting revenue growth of this segment.
In terms of application, the epinephrine market is segmented into anaphylaxis, cardiac arrest, superficial bleeding, respiratory disorders and others. The anaphylaxis segment accounted for largest revenue share in the global market in 2020, owing to increasing prevalence of anaphylactic allergic reactions globally and growing susceptibility to allergies. Anaphylaxis often occurs outside of a medical setting; for instance, after food ingestion or an insect sting, and the onset may be sudden and without warning. Severity varies from episode to episode even with an identical stimulus in the same patient. Recognition and diagnosis of anaphylaxis is sometimes difficult for health care professionals and for individuals without medical training. Prevalence of anaphylaxis is increasing significantly, even in developed countries across the globe. Approximately 50 million Americans develop different types of allergies each year. As a result, demand for epinephrine treatment is also increasing in order to reduce incidence of allergic reactions among an increasing number of individuals.
Distribution Channel Outlook:
Based on distribution channel, the epinephrine market is segmented into hospital pharmacies, retail pharmacies, and online pharmacies. The hospital pharmacies segment is projected to register fastest revenue CAGR in the global market between 2021 and 2030. Increasing patient visits to hospitals and individuals suffering from severe allergic conditions is among some of the prominent factors supporting revenue growth of this segment. According to Food Allergy Research & Education, around 200,000 Americans visit the emergency room every year due to food allergies. Besides, rising preference among patients to visit hospitals due to rising prevalence of cardiac diseases and lungs diseases, etc. is another factor contributing significantly to revenue growth of this segment.
North America epinephrine market led among other regional markets in the global market in terms of revenue share in 2020 and the trend is expected to continue over the forecast period. Factors such as increasing number of people suffering from life-threatening food allergies and rising prevalence of chronic diseases and allergic reactions, presence of robust healthcare infrastructure and advanced medical facilities, along with rapid launch of advanced epinephrine products and injections are other key factors contributing to steady revenue growth of the market in the region.
Asia Pacific epinephrine market is expected to register fastest revenue growth rate in the global market over the forecast period. Increasing awareness regarding effectiveness of treatment against life-threatening allergies in various countries in the region, rapid developments in the pharma industry, and high adoption rate of epinephrine injectors are some key factors driving revenue growth of the epinephrine market in Asia Pacific. Countries such as India, China, and Japan are registering new cases of anaphylaxis caused by food allergens, insect bites, and certain drugs. This is further augmenting demand for epinephrine treatment, and the trend is expected to continue going ahead.
Companies considered and profiled in the market study
Pfizer Inc., Mylan N.V, Teva Pharmaceuticals, Henry Schein Medical, Adamis Pharmaceuticals Corporation, Sandoz International GmbH, and Bausch Health Companies are some of the major companies included in the report.
Major companies are adopting both organic and inorganic growth strategies, including product launches, partnerships, agreements, collaborations, and expansions in order to maintain an advantage in the field of epinephrine.
- In June 2021, Alerje Inc., which is a food allergy management company based in Detroit, US, introduced a smartphone case equipped with auto-injector that effectively releases epinephrine during severe allergic reactions. Moreover, this case will also automatically alter the patients’ support circle through Alerje smartphone app, when a dose is discharged.
Segments Covered in the report
This report offers historical data and information as well as forecasts revenue growth at global, regional, and country level, and provides analysis of market trends for each segments and sub-segments from 2022 to 2030.
For the purpose of this report, has segmented the global epinephrine market on the basis of product type, application, distribution channel, and region:
Epinephrine Market Report Scope
Segments covered By Product Type Outlook, Application Outlook, Distribution Channel Outlook, Regional Outlook
By Product Type Outlook
Ampoules and Vials
By Application Outlook
By Distribution Channel Outlook
Middle East & Africa
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