The global high potency active pharmaceutical ingredients (HPAPI) market size was USD 16 Billion in 2022 and is expected to register a CAGR of 9.1% during the forecast period.
According to the latest report by Reports and Data, the Global High Potency Active Pharmaceutical Ingredients (HPAPI) market is expected to thrive over 2022-2030 due to the growing preference for the outsourcing of HPAPI manufacturing and rich pipeline with targeted therapeutic drugs. The concentration of technical expertise in the hands of a few major players and lack of universal regulatory policies and standards are factors poised to escalate the growth of the High Potency Active Pharmaceutical Ingredients (HPAPI) market.
Highly prominent in oncological research, HPAPI has gained popularity and thus seen a boost in demand. Scientists and researchers are always in the process of studying and discovering ways which can help in finding a cure to the lethal cancer disease. HPAPI have properties that make them useful in battling cancer, despite their high toxic level.
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The toxic nature of HPAPIs presents significant challenges and thus requires considerable investments for implementing specialized containment facilities that can keep employees safe from exposure which inturn is seriously costly to maintain. Contract manufacturers are required to heavily invest in building new facilities that are designed specifically for high potency active pharmaceutical ingredients (HPAPI) manufacturing, aside from the standard GMP production facilities; investments may sometimes amount to many dollars.Manufacturers may alos need to develop specialized facilities for HPAPI-antibody conjugations that include both biologics processing and potent-compound handling capabilities. As an example, in October 2015, ADC Biotechnology (UK), invested USD 10 million to create a producing facility for advanced anti-cancer drugs. These requirements of huge investments are probably going to restrain the expansion of the High Potency Active Pharmaceutical Ingredients (HPAPI) market.
Type Outlook:
Synthetic route of High Potency APIs dominated the general market in terms of revenue share as of 2020 due to the presence of huge manufacturers producing these sorts of molecules. Biotech HPAPI segment is predicted to be the fastest-growing and is predicted to grow at a lucrative rate of growth thanks to rising demand for cancer drugs and fueling research and development activities concerning it.
Application Type Outlook:
High potency active pharmaceutical ingredients (HPAPI) are extremely effective in pharmacologically active ingredients. They are highly specific in their action and offer significant efficiency even at low daily therapeutic doses. High potency active pharmaceutical ingredients (HPAPI) have the power to focus on precise disease cells and are, hence, utilized in formulations for highly potent drugs.
Owing to their target release characteristics, high potency active pharmaceutical ingredients (HPAPI) find major applications in target therapies for cancer. Globally, there’s a big growth within the incidence of cancer. Consistent with the WHO, in 2012, there have been 14.1 million new cancer cases, 8.2 million cancer deaths, and 32.6 million people living with cancer worldwide. The American Cancer Society estimated that as of January 2016, over 15.5 million Americans were affected by cancer, with more than 1.6 million new cancer cases expected to be diagnosed in 2022.
This growth within the number of cancer cases features a tremendous impact on the sales of cancer drugs across the world. According to a piece of writing published in Nature Reviews, the pharmaceutical industry’s 20 top-selling cancer drugs generate annual sales of over USD 50 billion worldwide, with Roche’s Rituxan, Avastin, and Herceptin in the leading position generating USD 21 billion in sales.
Regional Outlook:
The industry for top potential active pharmaceutical ingredients has been dominated by the Asia Pacific region. The CAGR for the region within the forecasted period is speculated at 11% by the top of the year 2028. Moreover, thanks to the event of major countries like India, China, and Japan, the region is predicted to carry a substantial share of the high potency active pharmaceutical ingredients industry.
Emerging economies like India, China, and the Middle East present high growth opportunities for players within the high potency active pharmaceutical ingredients market. In most of those regions, the high potency active pharmaceutical ingredients (HPAPI) market is predicted to register a high rate of growth within the coming years due to their huge population, increasing prosperity, and improving longevity (albeit at differing rates).
Diseases like musculoskeletal diseases, glaucoma, and specifically cancer have a big impact on the health status of individuals worldwide, with comparatively higher growth rates in developing countries. According to WHO, in 2014, nearly 66% of all cancer-related deaths occurred in developing countries. Additionally, GLOBOCAN 2012 found that 6.8 million new cancer cases were reported in 2012 in Asia; and if the trend continued, the numbers would exceed 8.4 million cases by 2022, indicating a rise of ~24%.
Furthermore, developing regions have lenient and versatile regulations, which make these markets highly lucrative for providers who are unable to satisfy the stringent standards set by the federal within the US. Moreover, developing countries like India and China offer extremely low manufacturing and labor costs and highly skilled labor; this encourages players in developed regions to take a position in the high potency active pharmaceutical ingredients market.
Market-o-Nomics:
- High Potency Active Pharmaceutical Ingredients (HPAPI) market is expected to thrive over 2022-2030 due to a growing preference for outsourcing HPAPI manufacturing and rich pipeline with targeted therapeutic drugs.
- Highly prominent in oncological research, high potency active pharmaceutical ingredients have gained popularity and thus seen a boost in demand.
- The cytotoxic nature of high potency active pharmaceutical ingredients presents significant handling challenges and thus requires heavy investments
- Synthetic route of High Potency APIs dominated the general market in terms of revenue share
- Owing to their target release characteristics, HPAPIs find major applications in target therapies for cancer.
- The industry for top potential active pharmaceutical ingredients has been dominated by the Asia Pacific region.
Competitive Landscape:
There are a lot of major companies in the market for HPAPI. However, most of them hail from the APAC region. Owing to this, the APAC region has the biggest contribution in the region. The top three participants that hold a major share in this market include Eli Lily, Novartis, and Bristol-Myers Squibb Company. Other players include Roche Diagnostics Limited, Sano Aventis, Hospira Inc., BASF AG, Covidien Plc, Boehringer Ingelheim GmbH, Merck & Co., Inc., Sigma Aldrich Corporation, Bayer AG, Carbogen Amcis AG, Lonza, and Teva Pharmaceuticals Industries Ltd.
Deal Landscape:
A lot of the pharmaceutical companies have extended help to the needy. At the top of the list is Bristol-Myers-Squibb Company which has decided to donate free medicine and healthcare aid to the poor. Then there is Teva Pharmaceuticals which isare partnering with Huddol and offering a virtual personal assistance to people. Karyopharm Therapeutics have started a trial of a new medicine across hospitals to check the effectiveness on COVID-19 patients. The coronavirus (COVID-19) pandemic will be a major factor impacting the future of HPAPI business. The report analyses the possible after effects of the outbreak on the sector and leading and emerging players in the industry.
Segments covered in the Report
This report forecasts volume and revenue growth at a global, regional, and country-level, and provides an analysis of the industry trends in each of the sub-segments from 2022 to 2030. For the purpose of this study, Reports and Data have segmented the global high potency active pharmaceutical ingredients market on the basis of type, application type, and region:
High Potency Active Pharmaceutical Ingredients (HPAPI) Market Report Scope
Segments covered By Type, Application Type, Regional Outlook
By Type
Synthetic
Biotech
By Application Type
Oncology
Glaucoma
Hormonal
Others
Regional scope
North America
Europe
Asia Pacific
Latin America
Middle East & Africa
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