Protein Crystallization and Crystallography Market USD 1.10 Billion in 2022

The global protein crystallization & crystallography market size was USD 1.10 Billion in 2020 and is expected to register a CAGR of 9.2% during the forecast period.

Increasing application of protein crystallization for elucidating membrane protein structure, continuous investments in research and development and on technological advancements, and rising adoption of protein therapeutics are some major factors expected to continue to drive market revenue growth over the forecast period. In addition, use of protein crystallization technique has been expanding into various fields such as biotechnology, pharmaceuticals, and chemicals among others, and these are some other key factors expected to drive revenue growth of the market over the forecast period.

Protein crystallization is the process of forming protein crystals and it depends on the solution that is supersaturated in the macromolecule but exhibits conditions that do not disrupt its natural state. Protein crystallization enables the formation of a systematic array of individual protein molecules in organized structures called crystals. These protein crystals are created for scientific and industrial purposes; primarily for the study of X-ray crystallography. Protein crystallization technique was first used for isolation and purification of proteins. The advent of X-ray crystallography gave rise to the importance to protein crystals as they could give three-dimensional structural information about biological macromolecules.

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Availability of atomic resolution structures offers a deep and unique understanding of protein function and helps to understand inner workings of a living cell. Currently, the only techniques that can generate atomic level structural images of biological macromolecules are X-ray crystallography and neutron diffraction. Increasing use of protein crystallization to understand structure of membrane proteins and use of crystallization as a powerful tool for protein purification and demonstrating chemical purity are key factors expected to contribute to market growth over the forecast period.

Increasing demand for protein therapeutics and rapid technological developments in protein crystallography are expected to continue to drive revenue growth of the market going ahead. Protein crystallography is widely used in drug discovery and development. Increasing burden of chronic and rare diseases have boosted need for novel and efficient drugs, which has led to a rapid increase in drug discovery and development activities. This is expected to further boost adoption of protein crystallography and drive market growth over the forecast period. However, high costs of instruments and lack of skilled professionals are some key factors that can hamper market growth to a certain extent over the forecast period. In addition, lack of standardized protocols for protein crystallization can also negatively impact market growth to a significant extent over the forecast period.

Market Dynamics:
Driver: Increasing demand for protein therapeutics is a key market revenue growth driving factor

Protein therapeutics have become an integral part of the healthcare industry over the recent past. Protein therapeutics have been widely used to treat various major diseases such as cancer, diabetes, and multiple sclerosis among others, owing to high specificity and low immunogenicity. In addition, protein therapeutics have many advantages over small-molecule drugs and have a low probability of interacting with normal biological processes and are hence well tolerated. Demand for protein therapeutics has increased considerably over the last few decades, majorly attributed to increasing prevalence of chronic diseases and rising awareness about protein therapeutics. Improvements in processes such as protein crystallography and implementation of standardized protocols are expected to positively impact market growth. X-ray protein crystallography plays a vital role in discovery of new therapeutics and treatments. High-throughput crystallography is considered a crucial tool for drug discovery processes and provides a quicker way for tailoring drug candidates to their targets. Increasing application areas and fields of protein crystallography is expected to further contribute to revenue growth of the market over the forecast period.

Restraint: High cost of equipment is a key factor restraining market growth

Highly advanced techniques such as nuclear magnetic resonance spectroscopy and X-ray crystallography are used to obtain information about protein structure. High initial costs associated with installation and working of equipment required for these techniques are expected to restrain market growth to a certain extent over the forecast period. In addition, lack of skilled professionals and experienced researchers are also expected to negatively impact market growth to a certain extent over the forecast period. Furthermore, absence of standardized protocol for crystallization of proteins is expected to restrain market growth to some extent during the forecast period.

Technology Outlook:

Based on technology, the global protein crystallization & crystallography market has been segmented into NMR and X-Ray crystallography. X-ray crystallography segment is expected to register significant revenue growth over the forecast period. X-ray crystallography is the most commonly used technique for determining the molecular and atomic structure of protein crystals, and increasing application of this technique for elucidating protein structure is expected to contribute significantly to revenue growth of this segment. X-ray crystal structures are also widely used in designing drugs for treatment of chronic and rare diseases and for developing efficient therapeutics, and this is expected to further fuel revenue growth of this segment over the forecast period.

Product & Service Outlook:

Based on product & service, the global protein crystallization & crystallography market has been segmented into instrument, software and services, and consumable. Consumable segment is expected to account for largest revenue share in the global market over the forecast period owing to increasing use and demand for reagent kits and microplates for proteomics research. The segment is further sub-segmented into reagents kits, microplates, crystal mounts, and other consumables. Growing demand for reagent kits owing to their rising applications in protein chemistry such as additives, detergent, precipitating agent, or to deliver ligands into protein crystals are expected to further drive revenue growth of this segment over the forecast period.

End-use Outlook:

Based on end-use, the global protein crystallization & crystallography market has been segmented into pharmaceutical companies, biotechnology companies, government institutes, and academic institutes. Biotechnology companies segment is expected to register a significant revenue CAGR over the forecast period, which can be attributed to increasing application of protein crystallization for genetic engineering, proteomics research, and protein engineering. Pharmaceutical company segment is also expected to register significant revenue growth over the forecast period owing to increasing application of protein crystallization in drug delivery processes and rising demand for protein therapeutics.

Regional Outlook:

Based on regional analysis, North America is expected to account for largest revenue share and register a CAGR of 33.2% over the forecast period. Robust growth can be attributed to rising investment and funding to accelerate proteomics research and for developing structure-based drug candidates, increasing proteomics research in academic and research institutes, and rising focus of key manufacturers on developing protein-based drugs and therapeutics.

Asia Pacific is expected to register a rapid revenue CAGR over the forecast period owing to rising awareness and adoption of protein crystallization in emerging economies such as India and China. Increasing novel drug design and development processes have resulted in increasing need to identify new ligands, which in turn has been boosting adoption of advanced technologies such as X-ray crystallography and Nuclear Magnetic Resonance (NMR) to understand protein structure. This is expected to further contribute to market growth in the region going ahead.

Competitive Landscape:

The global protein crystallization & crystallography market is highly competitive, comprising several regional and global players operating in various regions and countries. Key companies in the market are engaged in developing new technologies, mergers and acquisitions, and product innovation to gain a robust footing in the market. Major companies operating in the market include Rigaku Corporation, Hampton Research, Jena Bioscience GmbH, Bruker Corporation, Molecular Dimensions Ltd., Formulatrix, Inc., MiTeGen LLC, Biogenuix, Arinax Scientific Instrumentation, and HiMedia Laboratories, among others.

Some notable developments in the market include:

  • In March 2021, Bruker Corporation announced the launch of new plasma proteomics software, PaSER software v.1.1, which will allow “run & done” high-throughput 4D proteomics with immediate availability of identified peptides and protein groups after the experiment is done. In the same announcement, the company unveiled new consumables and software for chemical cross linking of proteins to study protein structure and interactions.

Segments Covered in the Report:

This report offers historical data and forecasts revenue growth at a global, regional, and country level, and provides analysis of the market trends in each of the sub-segments from 2019 to 2030. For this study, Reports and Data has segmented the global protein crystallization & crystallography market based on technology, product & service, end-use, and region:

Protein Crystallization & Crystallography Market Report Scope

Segments covered By Technology Outlook, Product and Service Outlook, End-Use Outlook, Regional Outlook

By Technology Outlook                

X-ray Crystallography

Nuclear Magnetic Resonance (NMR)

By Product and Service Outlook               

Consumables

Microplates

96 well-plates

48-well plates

24-well plates

Crystal Mounts and Loops

Reagents Kits/Screens

Other Consumables

Instruments

Liquid Handling Instruments

Automated

Manual

Crystal Imaging Instruments

Software & Services

By End-Use Outlook      

Pharmaceutical Companies

Biotechnology Companies

Government Institutes

Academic Institutes

Regional scope

North America

Europe

Asia Pacific

Latin America

Middle East & Africa

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